Everything That Researchers Need to Know About Epithalon

Because of its speculated anti-cell aging and immunological potential, Epithalon is a very popular peptide in the field of study. In this detailed breakdown, our knowledgeable staff discusses how Epithalon was incorporated into the study methodology.

Epithalon Peptide: What is it?

The following four amino acids are the constituents of the synthetic tetrapeptide known as Epithalon:

  • Amino acid (Ala)
  • Glutamic acid (Glu)
  • Aspartic acid (Asp)
  • Glycine (Gly)

Epithalon is an oligopeptide since it has less than twenty amino acids. The thymus gland produces the polypeptide epithalamin, followed by the peptide. Studies suggest that because of its tiny size, this peptide may penetrate cells and cell nuclei, where it has been suggested to induce and maintain DNA telomere lengthening, extending the time that cells can survive in vitro. Animal research indicates a correlation between this and longer lifespans.

Furthermore, Epithalon is speculated to boost melatonin generation. The pineal gland is the primary source of melatonin in the organsim; however, it is not the sole source. Melatonin plays a significant part in regulating circadian biological activities, the most prominent of which is the sleep cycle.

Research suggests that it may help regulate blood pressure and the autonomic nervous system of the cardiovascular system, improve immunological function and reduce inflammation in the gastrointestinal tract caused by inflammation.

Melatonin may also function in developing the central nervous system in fetuses and the early stages of development. Emerging research indicates that Epithalon may have research potential in various settings because they might increase telomere length and melatonin levels.

Epithalon Peptide Potential

Investigations purport that, as a class, oligopeptides may have many properties because they are very tiny. The transmission of biological information, the regulation of metabolic processes, and the influence on cell reproduction and apoptosis have all been hypothesized to be influenced by them.

In addition to potentially impacting broad-spectrum physiological function, Epithalon may be relevant in studies in the context of some particular disorders. Even though few studies have been conducted, most research on the peptide has been conducted on animals. The following is a summary of the Epithalon study results to date.

Epithalon Peptide and Cell Survival

During the process of DNA telomere lengthening, it has been indicated that Epithalon may effectively increase telomerase activity. Telomeres protect DNA integrity and are related to prolonged cell life. Longer telomeres are associated with longer cell survival. They tend to get shorter as a result of recurrent cell reproduction and the process of cell aging.

Mice genetically modified to have hyper-long telomeres had lower LDL cholesterol levels, higher glucose tolerance, and less DNA damage that occurs with aging over time. They also have a decreased risk of developing cancer and much higher life expectancy.

In a study that lasted for fifteen years, research models who were given intermittent courses of Epithalamion, which is the natural polypeptide source of Epithalon, appeared to have higher survival rates, improved cardiovascular function, fewer pulmonary illnesses, improved carbohydrate and lipid metabolism, and improved physical endurance in comparison to the controls.

The telomerase activity of epithalons has been connected to the possibility that they may prevent breast cancer, according to further investigations conducted on animals and in vitro.

Epithalon Peptide and the Neuroendocrine System

Findings imply that both Epithalon and melatonin may potentially alleviate several age-related neuroendocrine dysfunction symptoms and restore the normal circadian rhythm of the gonadotropin-releasing hormone in animals.

Additionally, it has been asserted that Epithalon may aid retinitis pigmentosa in mice and induce neurogenesis. Additional epigenetic data suggests epithalons may alter gene expression in neuron development.

A single laboratory has been responsible for most investigations published on Epithalon and related peptides. Further research is necessary to corroborate the results of these studies. Further research may add to this list of Epithalon’s potential properties.

Epithalon Peptide and Sleep

Melatonin is considered to be a crucial hormone that plays a role in regulating the circadian cycles of the organism. Melatonin may be quite significant in controlling autonomic functions, such as blood pressure, pulse, and temperature, as well as immunological response and glucose homeostasis.

In addition to maintaining a normal sleep-wake cycle, melatonin appears to play a key role in regulating these functions. Epithalon has been theorized to enhance the declining secretion pattern. Additionally, it has been implied to augment the circadian release of melatonin produced by the pineal gland.


Many unexplored areas need to be examined in the Epithalon study. Although well-regarded, a single group in Russia is the source of the only thorough data about the use of the peptide that has been made public to this point.

Visit www.corepeptides.com for more high-quality research compounds and educational peptide articles. Please note that none of the substances mentioned in this article have been approved for human or animal consumption and should not be used by unlicensed individuals outside of contained research settings such as laboratories. This article serves educational and informative purposes only.


[i] Khavinson, V. Kh. (2002). Peptides and aging. Neuro Endocrinol Lett. 23 Suppl 3:11-144. https://pubmed.ncbi.nlm.nih.gov/12374906/

[ii] Khavinson, V. Kh. 1, Bondarev, I.E., Butyugov, A.A. (2003) epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. 10.1023/a:1025493705728.

[iii] Muñoz-Lorente, M.A., Cano-Martin, A.C. & Blasco, M.A. Mice with hyper-long telomeres show less metabolic aging and longer lifespans. Nat Commun 10, 4723 (2019). https://doi.org/10.1038/s41467-019- 12664-x

[iv] Korkushko, O.V., Khavinson, V. Kh., Shatilo, Antonyk[1]Sheglova, I.A. (2011) Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: Results of 15-year follow-up. Bull Exp Biol Med 151 (3):343-347. 10.1007/s10517-011-1332-x

[v] Anisimov, V.N., Khavinson, V. Kh.,Alimova, I.N., Semchenko, A.V., Yashin, A.I. (2002). Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice, Bull Exp Biol Med 134(2):187-190. 10.1023/a:1021104819170

[vi] Korkushko, O.V., Lapin, B.A., Goncharova, N.D., Khavinson, V. Kh., Shatilo, V.B., Vengerin, A.A., et al. (2007). Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people. Adv Gerontol. 20 (1):74-85. https://pubmed.ncbi.nlm.nih.gov/17969590/

[vii] Khavinson, V., Razumovsky, M., Trofimova, S., Grigorian, R., Razumovskaya, A. (2002). Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett 23(4):365-368. https://pubmed.ncbi.nlm.nih.gov/12195242/

[viii] Khavinson, V., Diomede, F., Mironova, E., Linkova, N., Trofimova, S., Trubiani, O., Caputi, S., et al. (2020) AEDG peptide (epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism. Molecules 25(3):609 10.3390/molecules25030609

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