Chonluten Peptide and Studies in Transcription Regulation

Gene expression refers to using a gene’s instructions to guide the production of a protein or RNA component with specific functions. The health of cells and organisms depends on this mechanism. A body’s capacity to manifest its genes may deteriorate with age and inflammatory diseases. Further studies suggest that the potential of peptides like Chonluten to unblock altered gene expression is promising for further investigation.

Researchers speculate that the Chonluten peptide, produced from the ribosomal protein L7/L12, may exert some control on gene translation. The peptide has been proposed to have potential to regulate the immune system, circulatory system, and cancer cell growth.

Chonluten Peptide Overview

In the early 1990s, a team of scientists discovered the Chonluten peptide while researching the role of short peptides in controlling gene expression. Protein production requires the ribosomal protein L7/L12. Chonluten peptide appeared to have immunomodulatory potential, as the researchers suggested. Anti-inflammatory properties and blood pressure regulation were also suggested via study observations. [i]

Chonluten Mechanism of Action

Experiments in the lab suggest that the peptide may also have antiviral and anti-inflammatory properties, which, if properly utilized, could be researched in relation to chronic illnesses. Studies speculate that gene production and other cellular processes appear modulated by the Chonluten peptide. However, more study is required to assess and comprehend its definitive action.

Chonluten Peptide Research

Chonluten and Longevity 

Several studies suggest that two-, three-, and four-amino-acid peptides may extend animal life expectancy by an average of 40%. [ii][iii]. Regulation of gene expression, control of cellular processes, and suppression of natural and induced tumor growth are all involved methods.

The Chonluten peptide and other short peptides may interact actively with the DNA complex, as suggested by modeling studies [iv]. Based on the results of these studies, it appears that the peptide may regulate gene expression by interacting with DNA at different DNA regulatory areas.

Given this, it’s reasonable to infer that short peptides were among the earliest signaling molecules to control the processes of template-directed biosynthesis during evolution. This process may improve the potential for creating brief peptide-based immunoregulation, neuroprotection, microbiology, and virology medicines. [iv]

Chonluten and Intestinal Disorders 

Based on research [iv], it has been suggested that the Chonluten peptide may regulate gene responses, which in turn may lead to a decrease in inflammation and morphological alterations. Inflammation of the GI tract is a frequent sign of conditions like Crohn’s disease and ulcers that affect the digestive system. Studies speculate that Chonluten has the potential to reduce inflammation and treat gastrointestinal problems. Scientists have suggested a theory based on the impacts of peptides on lung illnesses, and now they’re trying to prove it. [v]

Chonluten and Bacterial Diseases 

Based on its action against multiple bacterial species, including Staphylococcus aureus and Escherichia coli, a 2019 study [vi] published in the Journal of Agricultural and Food Science suggested that Chonluten may have antimicrobial characteristics. Further research is necessary to explore this potential.

Conclusion

Research studies suggest that Chonluten peptide, a brief tripeptide, may have anti-inflammatory effects, antioxidant characteristics, and antimicrobial action against several bacterial species. The presently commercially accessible peptides are not approved or available for personal use and are strictly available for use in research and laboratory settings only. Only academic and scientific institutions are permitted to use Chonluten.

Please note that none of the items listed are approved for human or animal consumption. Laboratory research chemicals are only for in-vitro and in-lab use. Any kind of physical introduction is illegal. 

References

[i] Khavinson V, Linkova N, Kozhevnikova E, Dyatlova A, Petukhov M. Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers. Int J Mol Sci. 2022 Jul 13;23(14):7733. doi: 10.3390/ijms23147733. PMID: 35887081; PMCID: PMC9323678. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323678/

[ii] Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010 Apr;11(2):139-49. doi 10.1007/s10522-009-9249-8. Epub 2009 Oct 15. PMID: 19830585. https://pubmed.ncbi.nlm.nih.gov/19830585/

[iii] Voicekhovskaya, M.A., et al. “Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats.” Bulletin of Experimental Biology and Medicine, vol. 152, no. 3, Jan. 2012, pp. 357+. Gale Academic OneFile.

[iv] Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021 Nov 22;26(22):7053. doi: 10.3390/molecules26227053. PMID: 34834147; PMCID: PMC8619776. https://pubmed.ncbi.nlm.nih.gov/34834147/

[v] Khavinson VKh, Lin’kova NS, Dudkov AV, Polyakova VO, Kvetnoi IM. Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med. 2012 Mar;152(5):615-8. English, Russian. doi: 10.1007/s10517-012-1590-2. PMID: 22803148. https://pubmed.ncbi.nlm.nih.gov/22803148/

[vi] Zhu, Y., Wu, W., Zhou, Y., Huang, Y., Jin, J., & Cao, Y. (2019). Antibacterial activity of chonluten peptide against foodborne pathogens and spoilage bacteria. Journal of Agricultural and Food Chemistry, 67(25), 7113-7119. doi: 10.1021/acs.jafc.9b02621

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